Search results for "Cystic fibrosis gene"

The selective advantage of cystic fibrosis heterozygotes tested by aDNA analysis: A preliminary investigation

2000

Recently a heterozygote advantage was suggested to explain the high incidence (1:25 carrier individuals in Europeans) of the cystic fibrosis gene. This selective advantage was speculated to be due to a high resistance to chloride-secreting diarrhea, including cholera. Up to now the major efforts to test directly this hypothesis have been limited to animal models.